解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated t...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2842
更新日期:2015-04-01 00:00:00
abstract::Licochalcone A (LCA) is a natural product derived from the roots of Glycyrrhiza inflata exhibiting a wide range of bioactivities such as antitumor, anti-oxidant and anti-bacterial effects. Malignant pleural mesothelioma (MPM) is an extremely aggressive type of cancer with a poor prognosis because of its rapid progress...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2839
更新日期:2015-03-01 00:00:00
abstract::Bioinformatics and computational modeling offer innovative approaches to investigate cancer metabolism and predict the secondary and tertiary cellular responses. Dysregulation of metabolism has also been implicated in the pathophysiology of cancer. A significant proportion of patients with glioblastoma and hematologic...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2833
更新日期:2015-03-01 00:00:00
abstract::Despite the introduction of 13-cis-retinoic acid (13-cis-RA) into the current chemotherapy, more than half of high-risk neuroblastoma patients have experienced tumor relapses driven by chemoresistant cancer stem cells (CSCs) that can be isolated by their ability to grow as spheres. Although aldehyde dehydrogenase (ALD...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2801
更新日期:2015-03-01 00:00:00
abstract::Radiotherapy (RT) is one of the major modalities for non‑small cell lung cancer (NSCLC), but its efficacy is often compromised by cellular resistance caused by various mechanisms including the overexpression of epidermal growth factor receptor (EGFR). Although cis‑diamminedichloroplatinum(Ⅱ) (cisplatin, CDDP) has been...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2806
更新日期:2015-03-01 00:00:00
abstract::Triple negative breast cancer (TNBC) patients cannot be treated with endocrine therapy or targeted therapies due to lack of related receptors. These patients overexpress the epidermal growth factor receptor (EGFR), but are resistant to tyrosine kinase inhibitors (TKIs) and anti-EGFR therapies. Mechanisms suggested for...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2805
更新日期:2015-03-01 00:00:00
abstract::Macrophages are a major component of the leukocyte infiltrate of tumors and play a pivotal role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which macrophages promote HCC invasion are poorly understood. The present study was undertaken to investigate the relationship betwe...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2761
更新日期:2015-02-01 00:00:00
abstract::Paeonol, a potent antioxidant isolated from cortex moutan, possesses athero‑protective activity, yet the detailed mechanisms are not fully investigated. This study was conducted to explore the role of paeonol and its underlying mechanisms in RAW264.7 macrophages and apolipoprotein E‑deficient (ApoE(‑/‑)) mice. Paeonol...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2757
更新日期:2015-02-01 00:00:00
abstract::The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)‑proteasome and autophagy‑lysos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2773
更新日期:2015-02-01 00:00:00
abstract::Human breast cancer is a major cause of global morbidity and mortality in women and it is a process that involves numerous molecular and cellular alterations attributed to environmental substances and agents such as hormones. Bisphosphonates, such as pamidronate, are potent antiresorptive drugs used to the treatment o...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2955
更新日期:2015-01-01 00:00:00
abstract::Extrahepatic cholangiocarcinoma (CC) is an aggressive malignancy with dismal prognosis and characterized by early invasion, metastasis and postoperative recurrence. Therefore, understanding the main molecular mechanisms of this malignancy is the key for the development of novel and effective therapeutic strategies for...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2957
更新日期:2015-01-01 00:00:00
abstract::The prognosis of non-small cell lung cancer (NSCLC) patients who failed two or more treatment regimens remains very poor. We conducted a phase II study to explore the feasibility of personalized peptide vaccination (PPV), in which peptides are selected and administered based on the pre-existing host immunity before va...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2699
更新日期:2015-01-01 00:00:00
abstract::Esculetin (6,7-dihydroxycoumarin), a coumarin compound, is known to inhibit proliferation and induce apoptosis in several types of human cancer cells and is regarded as a promising chemotherapeutic agent. The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2700
更新日期:2015-01-01 00:00:00
abstract::Although neural and mesenchymal stem cells have been well-known to have a strong glioma tropism, this activity in induced pluripotent stem cells (iPSCs) has not yet been fully studied. In the present study, we tested tumor tropic activity of mouse iPSCs and neural stem cells derived from the iPSC (iPS-NSCs) using in v...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2702
更新日期:2015-01-01 00:00:00
abstract::This study defines the role of WWOX in the regulation of epithelial to mesenchymal transition. A group of 164 endometrial adenocarcinoma patients was studied as well as an ECC1 well-differentiated steroid-responsive endometrial cell line, which was transducted with WWOX cDNA by a retroviral system. The relationship be...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2964
更新日期:2015-01-01 00:00:00
abstract::Accumulation of epigenetic alterations causes inactivation of tumor suppressors and contributes to the initiation and progression of hepatocellular carcinoma (HCC). Identification of methylated genes is necessary to improve our understanding of the pathogenesis of HCC and develop novel biomarkers and therapeutic targe...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2965
更新日期:2015-01-01 00:00:00
abstract::Signet ring cell gastric cancer (SRCGC) has very poor prognosis worldwide, and studying its molecular characteristics is urgent for improving the outcome. However, few well-characterized SRCGC cell lines are available for research. Therefore, we established a novel cell line GCSR1, from a Chinese male SRCGC patient. C...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2966
更新日期:2015-01-01 00:00:00
abstract::This study suggests that speckle-type POZ protein (SPOP) may be a tumor suppressor gene and its prognostic value in human glioma. Real-time quantitative RT-PCR (qRT‑PCR), western blotting, and immunohistochemical staining were used to examine SPOP expression in glioma tissues and normal brain (NB) tissues. The relatio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2729
更新日期:2015-01-01 00:00:00
abstract::Although HIF-1α is considered an attractive target for the development of cancer therapies, like other transcriptional factors, it has been regarded as 'undruggable'. The decoy approach is a new class of antigene strategy that can be used to modulate the function of endogenous transcriptional factors. Here, we designe...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2715
更新日期:2015-01-01 00:00:00
abstract::This study was designed to identify epigenetically regulated genes and to clarify the contribution of epige-netic alteration to acquired resistance to epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs). We established a gefitinib‑resistant lung cancer cell line, PC9, which was originally gefitinib...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2733
更新日期:2015-01-01 00:00:00
abstract::Tumor metastases are the ultimate target in cancer therapy. In epithelial malignancies, the expression of high-mobility-group A2 (HMGA2) is associated with disease progression and the epithelial-mesenchymal transition (EMT), which is involved in the metastatic process. The present study assessed the clinical and molec...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2947
更新日期:2015-01-01 00:00:00
abstract::MUC16 (CA125) is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer (EOC). Expression of MUC16 is not detectable in the epithelial surface of normal ovaries. MUC16 expression is, however, common in serous EOC as well as in metastatic and recurrent tumors. Despite these observations,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2707
更新日期:2015-01-01 00:00:00
abstract::Breast cancer (BC) is the most frequently malignancy in women. Therefore, establishment of an animal model for the development of preventative measures and effective treatment for tumors is required. A novel heterogeneous spontaneous mammary tumor animal model of Kunming mice was generated. The purpose of this study w...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2657
更新日期:2014-12-01 00:00:00
abstract::Epithelial-mesenchymal transition (EMT) is thought to be a key step for cancer metastasis. Using an immunohistochemical approach with gastric carcinoma tissue, we found the expression of protease-activated receptor-1 (PAR1), along with a metalloproteinase known to activate PAR1, were associated with poorer prognosis, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2651
更新日期:2014-12-01 00:00:00
abstract::Lin28 is a family of RNA binding proteins and microRNA regulators. Two members of this family have been identified: Lin28A and Lin28B, which are encoded by genes localized in different chromosomes but share a high degree of sequence identity. The role of Lin28B in androgen-independent prostate cancer (AIPC) is not wel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2647
更新日期:2014-12-01 00:00:00
abstract::Although the incidence of brain metastasis in gastric cancer is relatively low, its prevalence may increase with improved therapy and longer survival tumors. The molecular mechanisms underlying brain metastases are not well understood. To gain insight into the mechanism of brain metastasis, we studied differences in m...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2680
更新日期:2014-12-01 00:00:00
abstract::Cholangiocarcinoma (CCA) is a lethal malignancy which occurs with relatively high incidence in Thailand. This cancer is often difficult to diagnose and associated with high mortality. The secretome, containing the secreted proteins from cells, are potentially useful as biomarkers of cancers. Since three-dimensional (3...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2636
更新日期:2014-11-01 00:00:00
abstract::Spindle cell tumors are clinically heterogeneous but morphologically similar neoplasms that can occur anywhere, mostly in adult patients. They are treated primarily with surgery to which is often added adjuvant or neoadjuvant radiation. Sub-classification of spindle cell sarcomas requires integration of histology, cli...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2605
更新日期:2014-11-01 00:00:00
abstract::The α6 integrin subunit (α6) has been implicated in cancer cell migration and in the progression of several malignancies, but its role in tumor angiogenesis is unclear. In mice, anti-α6 blocking antibodies reduce tumor angiogenesis, whereas Tie1-dependent α6 gene deletion enhances neovessel formation in melanoma and l...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2631
更新日期:2014-11-01 00:00:00
abstract::Anisi stellati fructus (ASF), commonly known as star anise, has long been used as a traditional Chinese medicine to treat inflammation, nervousness, insomnia and pain. In recent studies, it has been demonstrated that ASF possesses anti-bacterial, anti-fungal and anti-oxidant activities, as well as exhibits inhibitory ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2606
更新日期:2014-11-01 00:00:00
abstract::MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether miRNAs regulate the SIRT1 and its downstream...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2596
更新日期:2014-11-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis of all malignancies, and current therapeutic options do not target cancer stem cells (CSCs), which may be the reason for the extreme aggressiveness. The dietary agents sulforaphane and quercetin enriched e.g., in broccoli, and the main and best studied gre...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2539
更新日期:2014-10-01 00:00:00
abstract::Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles in tumorigenesis and progression of multiple tumors. The present study aimed to investigate the clinical significance of CDC20 in hepatocellular carc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2559
更新日期:2014-10-01 00:00:00
abstract::Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of histone deacetylase 3 (HDAC3) correlate with malignant phenotype. However, the expression patterns and biological role of HDAC3 in pancreatic cancer remain unclear. I...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2568
更新日期:2014-10-01 00:00:00
abstract::Pristimerin (PM), a quinonemethide triterpenoid, is a promising anticancer agent with potent antiproliferative and apoptosis-inducing activities against cancer cell lines. However, the anticancer activity and mechanisms of PM in prostate cancer cells have not been adequately investigated. Here we report that the degra...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2561
更新日期:2014-10-01 00:00:00
abstract::Patients with non-small cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangements generally respond to ALK inhibitors such as crizotinib. However, some patients with EML4-ALK rearrangements respond poorly to crizotinib. Hypoxia is involved in ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2574
更新日期:2014-10-01 00:00:00
abstract::The CXC chemokine receptor 7 (CXCR7) has been reported to be involved in cell growth, metastasis and apoptosis in certain cancers. However, the function and molecular mechanisms of CXCR7 in human colorectal cancer (CRC) are still undefined. In the present study, sixty-eight cases of CRC tissues and corresponding adjac...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2547
更新日期:2014-10-01 00:00:00
abstract::Hypoxia regulates the expression of genes that promote tumor growth, angiogenesis and invasion. We previously studied hypoxic tumor cells in vitro and from hepatic metastases of colorectal cancer and determined several potential prognostic factors for hepatocellular carcinoma (HCC). In this study, we evaluated the pro...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2519
更新日期:2014-09-01 00:00:00
abstract::Hepatocyte growth factor (HGF) is a key growth factor linked to promoting cancer progression and angiogenesis. The present study identifies repulsive guidance molecule b (RGMb), a bone morphogenetic protein (BMP) co-receptor, as a gene whose expression is regulated by HGF and explores the potential of RGMb to contribu...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2508
更新日期:2014-09-01 00:00:00
abstract::Multiple myeloma (MM) patients initially respond to conventional therapy, however, many develop resistance and have recurrences. We have reported in other tumors that the transcription factor Yin Yang 1 (YY1) is a resistant factor and, thus, we hypothesized that YY1 may be over-expressed in MM. Significantly, higher e...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2511
更新日期:2014-09-01 00:00:00